Cultural dynamism and business vitality in medium-sized cities—evidence and proposals for sustainable development

This work uses tools recently designed to conduct analyses and proposals around the cultural development of medium-sized cities. The Cultural and Creative Cities Monitor model, or CCCM, is first applied to the 81 cities in Spain with between 50, 000 and 100, 000 inhabitants. We also refer to the UNESCO Culture/2030 Indicators, specifically indicator 8 (Cultural companies), to in-vestigate whether cultural dynamism is related to business vitality in those cities. Our observation of the 29 CCCM indicators and the C3 index, which synthesizes cultural performance, is explained, and these data are complemented with cultural business data (on assets, benefits, and jobs) from a sample of 13, 204 firms. The C3 index values reveal significant differences in the cultural and creative performance of the selected cities according to their location (metropolitan or non-metropolitan) and their administrative rank. Moreover, when comparing the C3 index with the indicators on business activity, evidence indicates a clear positive relationship between cultural dynamism and firm vitality. These results support the contribution of culture to the sustainable development of me-dium-sized Spanish cities and further establish the suitability of the tools used to assist cities in designing appropriate cultural policies

RunScribe Sacral Gait Lab™ Validation for Measuring Pelvic Kinematics during Human Locomotion at Different Speeds

Optoelectronic motion capture systems are considered the gold standard for measuring walking and running kinematics parameters. However, these systems prerequisites are not feasible for practitioners as they entail a laboratory environment and time to process and calculate the data. Therefore, this study aims to evaluate the validity of the three-sensor RunScribe Sacral Gait Lab™ inertial measurement unit (IMU) in measuring pelvic kinematics in terms of vertical oscillation, tilt, obliquity, rotational range of motion, and the maximum angular rates during walking and running on a treadmill. Pelvic kinematic parameters were measured simultaneously using an eight-camera motion analysis system (Qualisys Medical AB, GÖTEBORG, Sweden) and the three-sensor RunScribe Sacral Gait Lab™ (Scribe Lab. Inc. San Francisco, CA, USA) in a sample of 16 healthy young adults. An acceptable level of agreement was considered if the following criteria were met: low bias and SEE ( 0.90), and good reliability (ICC > 0.81). The results obtained reveal that the three-sensor RunScribe Sacral Gait Lab™ IMU did not reach the validity criteria established for any of the variables and velocities tested. The results obtained therefore show significant differences between the systems for the pelvic kinematic parameters measured during both walking and runningThe State Research Agency (SRA)The European Regional Development Fund (ERDF) with the project EDUSPORT (REF: PID2020-115600RB-C21

Cultural and creative ecosystems in medium-sized cities: Evolution in times of economic crisis and pandemic

This article seeks to forecast the short-and medium-term impacts of the coronavirus pandemic on the cultural and creative ecosystems of the 81 cities in Spain with between 50, 000 and 100, 000 inhabitants. Data on employment in nine sectors (per NACE Rev. 2) support the characterization of cultural ecosystems based on their dynamism, specialization, and propensity to form clusters (thanks to the co-location of certain sectors, meant to generate inter-sectoral spillovers and cross-sector synergies). The applied methodology consists of comparing these three attributes during and following the 2008 financial crisis. Then, any changes observed are interpreted in light of arguments from the COVID-19 literature, and from our own analysis, in order to assess the probability of recurrence (or nonrecurrence) during the current pandemic. Throughout this process, the metropolitan or non-metropolitan position of cities is taken into consideration. A first conclusion is that, as in the financial crisis, the behavior of ecosystems during the pandemic will be asymmetric. Secondly, metropolitan and non-metropolitan cities will maintain their distinctive sectoral specializations. Non-metropolitan cities appear to be more vulnerable for their strong connection to creative sectors most affected by the pandemic, although some can take advantage of good cultural supply and proximity to metropolitan centers. Metropolitan cities seem more secure, thanks to the higher presence of less vulnerable sectors (due to elevated and accelerating digitization). Nevertheless, most functional clusters were diminished during the financial crisis, and it seems unlikely that sectoral co-locations will re-emerge in a post-pandemic scenario as a business strategy, at least in the short term. Beyond these forecasts, we recommend dealing with certain structural failures of these ecosystems, especially the vulnerability and precariousness of most cultural and creative companies and workers

Serum micrornas as tool to predict early response to benralizumab in severe eosinophilic asthma

Severe eosinophilic asthma poses a serious health and economic problem, so new therapy approaches have been developed to control it, including biological drugs such as benralizumab, which is a monoclonal antibody that binds to IL-5 receptor alpha subunit and depletes peripheral blood eosinophils rapidly. Biomarkers that predict the response to this drug are needed so that microRNAs (miRNAs) can be useful tools. This study was performed with fifteen severe eosinophilic asthmatic patients treated with benralizumab, and serum miRNAs were evaluated before and after treatment by semi-quantitative PCR (qPCR). Patients showed a clinical improvement after benralizumab administration. Additionally, deregulation of miR-1246, miR-5100 and miR-338-3p was observed in severe asthmatic patients after eight weeks of therapy, and a correlation was found between miR-1246 and eosinophil counts, including a number of exacerbations per year in these severe asthmatics. In silico pathway analysis revealed that these three miRNAs are regulators of the MAPK signaling pathway, regulating target genes implicated in asthma such as NFKB2, NFATC3, DUSP1, DUSP2, DUSP5 and DUSP16. In this study, we observed an altered expression of miR-1246, miR-5100 and miR-338-3p after eight weeks of benralizumab administration, which could be used as early response markers.This manuscript was funded by Fondo de Investigación Sanitaria–FIS and FEDER (Fondo Europeo de Desarrollo Regional) [PI15/00803, PI18/00044, and FI16/00036], CIBER de Enfermedades Respiratorias (CIBERES), Merck Health Foundation funds, and Ministerio de Ciencia, Innovación y Universidades (RTC-2017-6501-1

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access

Reviewing the use of resilience concepts in forest sciences

Purpose of the review Resilience is a key concept to deal with an uncertain future in forestry. In recent years, it has received increasing attention from both research and practice. However, a common understanding of what resilience means in a forestry context, and how to operationalise it is lacking. Here, we conducted a systematic review of the recent forest science literature on resilience in the forestry context, synthesising how resilience is defined and assessed. Recent findings Based on a detailed review of 255 studies, we analysed how the concepts of engineering resilience, ecological resilience, and social-ecological resilience are used in forest sciences. A clear majority of the studies applied the concept of engineering resilience, quantifying resilience as the recovery time after a disturbance. The two most used indicators for engineering resilience were basal area increment and vegetation cover, whereas ecological resilience studies frequently focus on vegetation cover and tree density. In contrast, important social-ecological resilience indicators used in the literature are socio-economic diversity and stock of natural resources. In the context of global change, we expected an increase in studies adopting the more holistic social-ecological resilience concept, but this was not the observed trend. Summary Our analysis points to the nestedness of these three resilience concepts, suggesting that they are complementary rather than contradictory. It also means that the variety of resilience approaches does not need to be an obstacle for operationalisation of the concept. We provide guidance for choosing the most suitable resilience concept and indicators based on the management, disturbance and application context

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

How does high-intensity intermittent training affect recreational endurance runners? Acute and chronic adaptations: A systematic review

Objective: This systematic review aimed to critically analyze the literature to determine how high-intensity intermittent training (HIIT) affects recreational endurance runners in the short- and long-term. Methods: Electronic databases were searched for literature dating from January 2000 to October 2015. The search was conducted using the key words “high-intensity intermittent training” or “high-intensity interval exercise” or “interval running” or “sprint interval training” and “endurance runners” or “long distance runners”. A systematic approach was used to evaluate the 783 articles identified for initial review. Studies were included if they investigated HIIT in recreational endurance runners. The methodological quality of the studies was evaluated using the Physiotherapy Evidence Database (PEDro) scale (for intervention studies) and the modified Downs and Black Quality Index (for cross-sectional studies). Results: Twenty-three studies met the inclusionary criteria for review. The results are presented in 2 parts: cross-sectional (n = 15) and intervention studies (n = 8). In the 15 cross-sectional studies selected, endurance runners performed at least 1 HIIT protocol, and the acute impact on physiological, neuromuscular, metabolic and/or biomechanical variables was assessed. Intervention studies lasted a minimum of 4 weeks, with 10 weeks being the longest intervention period, and included 2 to 4 HIIT sessions per week. Most of these studies combined HIIT sessions with continuous run (CR) sessions; 2 studies' subjects performed HIIT exclusively. Conclusion: HIIT-based running plans (2 to 3 HIIT sessions per week, combining HIIT and CR runs) show athletic performance improvements in endurance runners by improving maximal oxygen uptake and running economy along with muscular and metabolic adaptations. To maximize the adaptations to training, both HIIT and CR must be part of training programs for endurance runners